End of this page section.
Go to overview of page sections.
Begin of page section: Additional information:
End of this page section.
Go to overview of page sections.
Postdoc-Pool Projects University of Graz
Begin of page section: Contents:
Optimal Control Techniques for Electrocardiology
Contact person: Univ.-Prof. Dr. Karl Kunisch Institute of Mathematics and Scientific Computing E-Mail: karl.kunisch(at)uni-graz.at Phone.: +43 (0)316 380 – 5162 (-5160) |
BioTechMed-Graz Postdoc: Armin Rund, Dipl.-Math. Dr.rer.nat. |
Research partners:
New methods will be developed, which allow determining the optimal placement of electrodes for a given number of available electrodes. |
Neuroprotective effects and mechanisms of spermidine treatment in different models of Alzheimer`s disease
Contact person: Univ.-Prof. Dr. Frank Madeo Institute of Molecular Biosciences E-mail: frank.madeo@uni‑graz.at Phone: +43 (0)316 380 – 8878 |
BioTechMed-Graz Postdoc: Cornelia Sommer-Ruck, Dr.rer.nat. MSc. |
Research partner:
Alzheimer’s disease (AD), a neurodegenerative disorder and the most common cause of dementia worldwide, is characterized by age-dependent neuronal loss and cognitive decline, accompanied by extracellular accumulation of amyloid-β 42 peptide. The clearance of these deposits is critical for the maintenance of neuronal function – and can be achieved e.g. by autophagy, a lysosomal degradation pathway that can be enhanced by the natural polyamine spermidine. Project aim We will take advantage of vertebrate and invertebrate models of AD in order to dissect the impact of spermidine administration on different aspects of neurodegeneration, including ageing and other disease-associated risk factors, as well as short- and long-term memory and further neuronal characteristics. In order to gain a more complex insight into potential impacts of spermidine feeding on AD our studies will be extended to relevant murine models. To complement conventional behavioral and biochemical approaches we will use magnetic resonance imaging (MRI) as an innovative technique for in vivo analyses of AD scenarios. In order to deepen our understanding of the overall consequences of spermidine administration targeted metabolite- and proteome analyses will be performed. Following this approach we hopefully provide evidence for and unravel the presently uncharacterized pathways leading to spermidine-induced neuronal protection. |
Bacterial metabolite signal molecules in the intestinal microbiota: Who is talking? Who is listening?
Contact person: Ao. Univ.-Prof. Dr. Ellen L. Zechner Institute of Molecular Biosciences E-mail: ellen.zechner(at)uni-graz.at Phone.: +43 (0)316 380 – 5624 |
BioTechMed-Graz Postdoc: Sabine Kienesberger-Feist, Mag. Dr.rer.nat. |
Research partners:
|
Role of oral biological barriers in functional drug delivery
Contact person: Priv.-Doz. Dr. Eva Roblegg Institute for Pharmaceutical Sciences E-mail: eva.roblegg(at)uni-graz.at Phone.: +43 (0)316 380 – 8888 |
BioTechMed-Graz Postdoc: Birgit Teubl, Mag.pharm. Dr. |
Research partners:
|
Facilitating Cognition: The brain enhancing potential of brain stimulation techniques
Contact person: |
BioTechMed-Graz Postdoc: Shane Fresnoza, Ph.D |
Research partners:
Human performance and social success depend critically on the capacity of the human brain to solve complex tasks. Consequently, there is much interest in methods that can non-invasively enhance brain functions. Non-invasive brain stimulation (NIBS) techniques like transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or repetitive transcranial magnetic stimulation (rTMS) can be used to transiently facilitate or inhibit cortical processing in targeted brain areas. Evaluating the effects of NIBS techniques on brain function and behaviour can provide a better understanding of the human brain. Furthermore, evidence-based NIBS intervention protocols hold clinical potential, for example, in targeting the enhancement of impaired performance in the elderly and children with learning difficulties. In the present project, NIBS techniques are being used to enhance human information processing, such as, for example, motor learning, attention and memory. The efficacy of different brain stimulation protocols on the enhancement of brain function will be evaluated for young (18-35 years) and older healthy adults (55-70 years). |
Neurofeedback as a tool for cognitive training in multiple sclerosis
Contact person: Assoz.-Univ. Prof. Dr. Guilherme Wood Institute of Psychology E-mail: guilherme.wood@uni-graz.at Phone: +43 (0)316 850 – 8541 |
BioTechMed-Graz Postdoc: Silvia Erika Kober, Mag. Dr.rer.nat. |
Research Partners:
Multiple sclerosis (MS) is a chronic neuroinflammatory disease with a neurodegenerative component, which may lead to physical, cognitive and psychiatric problems. Cognitive deficits can start at an early stage of the disease and compromise central aspects of quality-of-life of MS patients. In this context, neurofeedback (NF) might be an alternative and innovative rehabilitation tool to improve cognitive functions in MS, overcoming some critical draw-backs of traditional cognitive rehabilitation. Using NF, individuals can learn to modulate their own brain activity by means of real-time feedback of different brain parameters, which has positive effects on cognitive and affective functioning. NF has been successfully employed in ADHD, epilepsy, depression, as well as in stroke patients. Similar evidence on MS lacks completely. Within an EU project targeting stroke patients (CONTRAST, FP7-287320), a consortium including the Department of Psychology of the University of Graz developed a full-functional NF system called COALA. COALA covers highly innovative aspects of cognitive rehabilitation such as home-based training, remote supervision, or an easy-to-use and intuitive technology. In cooperation with the Department of Neurology of the Medical University Graz, which has established an ambulatory and an extensive database of MS patients, COALA will be adapted and extended to optimize cognitive rehabilitation in MS. By targeting cognitive functioning through NF, COALA goes beyond the state-of-the-art of cognitive rehabilitation in MS patients and has the potential to improve cognitive functions at low cost and with higher efficiency than traditional cognitive training approaches. |
End of this page section.
Go to overview of page sections.
Begin of page section:
End of this page section.
Go to overview of page sections.