Prinicipal Investigator
Assoz. Prof. Priv.-Doz. Dr.rer.nat. Simon Sedej
Klinische Abteilung für Kardiologie
Medizinische Universität Graz
Medizinische Universität Graz
INTERACD+ - Integrating exercise and NAD+ to reduce cardiometabolic risk
The INTERACD+ consortium will study the preventive potential of nicotinamide adenine dinucleotide (NAD+) replenishment combined with exercise on obesity-related cardiometabolic syndrome. We aim to (1) uncover NAD+ and exercise-driven metabolic outcomes and mechanisms in a preclinical rat model of cardiometabolic syndrome, (2) analyze an existing prospective human cohort at cardiometabolic risk, and (3) perform a first-in-human pilot feasibility trial by combining an NAD precursor supplementation with exercise in patients at cardiometabolic risk.
Consortium
- Marion Mussbacher, Institute of Pharmaceutical Sciences, University of Graz
- Tobias Eisenberg, Institute of Molecular Biosciences, University of Graz
- Renate Schreiber, Institute of Molecular Biosciences, University of Graz
- Andreas Prokesch, Chair of Cell Biology, Histology and Embryology, Medical University of Graz
- Dirk von Lewinski, Clinical Department of Cardiology, Med Uni Graz
- Peter Rainer, Clinical Department of Cardiology, Med Uni Graz
