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Vortrag Elisabeth Grohmann, Faculty of Life Sciences and Technology, Beuth University of Applied Sciences Berlin, Germany


Am Mittwoch, 24.10.2018 findet um 16 Uhr in der Humboldtstraße 48 (SR 44.32) ein Vortrag von Frau Prof. Elisabeth Grohmann (Faculty of Life Sciences and Technology, Beuth University of Applied Sciences Berlin) zum Thema "Novel strategies to prevent colonization and resistance spread by multiresistant pathogens: a transcriptomics approach" statt.

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"Novel strategies to prevent colonization and resistance spread by multiresistant pathogens: a transcriptomics approach"

The occurrence of dangerous multi-resistant bacterial pathogens is increasing worldwide and at the same time only a few new antibiotics are in the pipeline. Thus, there is an urgent need for the development of innovative strategies to fight infections by multi-resistant pathogens and the spread of antibiotic resistances. One alternative are bimetallic antimicrobial surfaces against which no resistance has developed so far. Such an antimicrobial surface coating is AGXX© consisting of micro-galvanic elements of silver and ruthenium, surface-conditioned with ascorbic acid. AGXX© inhibits the growth of multi-resistant pathogens, such as pathogenic Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, MRSA (methicillin-resistant Staphylococcus aureus) and Enterococcus faecalis efficiently. In addition it was shown to strongly reduce biofilm formation of potent biofilm formers such as clinical MRSA isolates and P. aeruginosa.
A mechanism of action of the antimicrobial coating has been proposed on basis of RNA-Sequencing and Reverse Transcription quantitative PCR studies on MRSA and E. faecalis exposed to the antimicrobial for different time-periods.

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