Mahmoud Abdellatif

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Targeting mitochondria-autophagy circuits in heart failure



Mahmoud Abdellatif, MSc PhD
Division of Cardiology
Medical University of Graz

At least half of heart failure patients do not exhibit a major deficit in cardiac contractility; instead, they present with cardiac stiffness and impaired relaxation. The incidence of such preserved ejection fraction heart failure (HFpEF) sharply increases with age, and is currently the leading cause of hospitalization in the elderly. Thus far, there are limited therapeutic options for HFpEF and improving patient survival remains challenging.


To this end, emerging preclinical evidence suggests a link between HFpEF and dysfunctional cellular quality control mechanisms, such as autophagy. Therefore, we devised this project to investigate how disturbances in autophagy-dependent turnover of cardiac proteins and organelles, including mitochondria, contribute to the pathogenesis of HFpEF, and whether they can be targeted for HFpEF therapy. Eventually, the knowledge gained will help us identify suitable therapeutics and examine their potential effects in experimental models of HFpEF. This hypothesis-driven approach might have major clinical implications for millions of patients with HFpEF worldwide.


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Cooperating partners

 Universität Graz  TU Graz  Med-Uni Graz 

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BioTechMed-Graz Coordination Office

Mozartgasse 12/II
8010 Graz

Mobile:+43 664 30 10 141

Mag. Julia Rohrer

Phone:+43 316 380 - 5022

Margit List-Schleich, MA

Phone:+43 316 380 - 5020

MMag. Christina Prix

Phone:+43 316 380 - 5022
In maternity leave

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