Beginn des Seitenbereichs: Unternavigation:

Ende dieses Seitenbereichs.
Zur Übersicht der Seitenbereiche.

Beginn des Seitenbereichs: Zusatzinformationen:

Neuigkeitensuche

Ende dieses Seitenbereichs.
Zur Übersicht der Seitenbereiche.

Beginn des Seitenbereichs: Inhalt:

Nachlese Flagship Lecture - Maria Mittelbrunn

M. Abdellatif, M. Mittelbrunn, R. Zechner

Maria Mittelbrunn vom Centro de Biologia Molecular Severo Ochoa, hielt am 22.5. vor rund 50 Teilnehmer*innen die Flagship Lecture zum Thema "Immunometabolism at the crossroad between inflammation and aging".

Die mit dem ERC Consolidator Grant ausgezeichnete Forscherin gab Einblicke in die noch nicht veröffentlichten Ergebnisse ihres Grants "Let T Be": 

As in many other cells and tissues, cells of the immune system present mitochondrial decline with age. To investigate the consequences of the aging of the immune system, we have induced age-associated mitochondrial dysfunction prematurely in T cell. Targeting mitochondrial function in T cells recapitulates metabolic, phenotypic and functional features of aged T cells, including susceptibility to infections and premature inflammaging. We found that inducing age-associated mitochondrial decline in T lymphocytes, does not only cause an immunometabolic dysfunction that drives T cell senescence, but actually causes a general, body-wide deterioration of health with multiple aging-related features, including metabolic, musculoskeletal, cardiovascular and cognitive alterations, altogether resulting in premature death. Thus, premature aging of T lymphocytes may be ‘contagious’, driving a generalized acceleration of aging throughout multiple organ systems. Our results place the metabolism of T cells at the crossroad between inflammation, senescence and aging, highlighting that immunometabolism can be a therapeutic target to delay aging. This presentation will decode the molecular mechanism by which defective T cells contribute to inflammaging and age-related diseases and will discuss novel therapeutic opportunities to promote healthy aging.

Ende dieses Seitenbereichs.
Zur Übersicht der Seitenbereiche.